Abstract: The topological relationship between spatial objects is one of the most important aspects in GIS modeling, and it is the basis of spatial query and analysis. The description of spatial relationships has been paid more attention in the field of GIS. At present, the research on topological relation model for spatial objects was usually described simple objects, the research of a regions with a hole are comparatively fewer, it’s research has important theory meaning. this paper based on the 11th reference literature, used the point-set topology theory, redefined the regions with holes. By analyzing the evolution plans of simple area objects’ topological relations, put forward a new method which can describe the special topological relations of regions with a hole, and used the new method to discussed the topological relations of two regions with a hole. Through the experiment, in thoery, it has been proved that this method is feasible, can provide a theoretical method for improving the modeling and analysis capabilities of GIS.