Abstract: CBERS02B is the third satellite of CBERS (China-Brazil Earth Resources Satellite) series satellites, which was launched in Sep. 2007, and works normally more than two years since then. The sensor on satellite is usually attenuated because of the intense ultraviolet radiance and cold space environment at the top of atmosphere. Three methods had been used to calibrate the CBERS02B CCD Camera in time series, which were desert sense calibration method, pseudo-invariance target calibration method and cross-calibration method, and the CBERS02B CCD calibration coefficients of three methods during 2007-2008 had been calculated. Desert sense calibration method supposes that the test site ground and atmospheric is invariance, and only the solar angle and Earth-Sun distance are changed. Pseudo-invariance target calibration method considers that test site atmospheric is variance, but the ground reflectance is steady. Cross-calibration method uses MODIS as reference sensor, and calculates time series calibration coefficient of CBERS02B CCD camera by processing the image pairs of MODIS and CBERS02B CCD image of Dunhuang test site. The relative differences of three methods’ calibration coefficients were less than 10%. Furth more, CBERS02B official calibration coefficient was used to validate the precision of three methods’ calibration coefficients and the results were very ideal. In the end, the advantage and disadvantage of time series calibration method were analyzed, which would be useful for other similar satellites in future.